Ensuring sustainable development (of the country, its regions, businesses, and individuals) is closely correlated with the formation of conditions necessary to improve the life quality. Understanding this phenomenon, assessing its level, development, and implementation of appropriate mechanisms at different levels of the socio-economic system is an important scientific task. This task not only does not lose its relevance but on the contrary – increases due to the rapid transformation and challenges. The monograph consists of six parts. It highlights the results of research on philosophical and psychological aspects of the phenomenon of life quality, financial and economic tools to improve life quality, the role of physical culture and sports in shaping a healthy lifestyle as a guarantee of quality factors of strengthening personal resources and improving the life quality, mechanisms of legal responsibility in the globalization context, as well as an interdisciplinary approach to solving the problem of improving the life quality. The first part of the monograph is devoted to determining the nature and level of life quality at different levels of the hierarchy of socio-economic systems and socio-psychological adaptation of various groups to rapid transformations, mobility, and consequences of the COVID-19 pandemic. The second part of the monograph contains the research results on the impact of entrepreneurship in management, administration, and other financial and economic instruments on the quality of life of different groups. The third part of the monograph highlights the achievements concerning the role of physical culture and sports in shaping the life quality of different groups of the population, among which special attention is paid to applicants for educational institutions. 8 The fourth part of the monograph reveals the development of personal potentials and other complex systemic formations, the influence of spiritual and humanistic factors on the creation of life quality. The fifth part of the monograph is devoted to the issues related to the formation and implementation of mechanisms of legal liability in the context of globalization, namely: regulation of business, development of legislation on criminal liability in the context of globalization, and others. The sixth part contains the results of solving problems of improving the life quality, which are based on an interdisciplinary approach in public administration, medicine, education, tourism, etc. The authors’ team hopes that the monograph contains information relevant to scientists, students, and anyone interested in various aspects of improving the quality of life.